口服RET抑制剂Retevmo（selpercatinib）

On May 8, 2020, the FDA of the US Food and Drug Administration approved the listing of oral RET inhibitor Retevmo(selpercatinib), a subsidiary of Lilly, for the treatment of: 1) adult patients with advanced non-small cell lung cancer (NSCLC) with positive RET fusion; 2) Adults and children over the age of 12 who need systemic treatment (oral or injection) for advanced or metastatic RET mutant medullary thyroid cancer; 3) Adults and children over 12 years old with advanced or metastatic RET fusion positive thyroid cancer who need systemic treatment and are resistant to radioiodine therapy.
Oral RET inhibitor Retevmo(selpercatinib)_ Hong Kong Jimin Pharmaceutical

[dosage and administration method of Retevmo (selpercatinib)]
Recommended dose based on body weight: ① less than 50 kg: 120 mg; ② 50kg and above: 160mg.
■ Take orally twice a day (about once every 12 hours) until the disease progresses or unacceptable toxicity occurs.
■ Swallow the whole capsule without crushing or chewing capsule shell.
■ Do not miss any dose unless the next scheduled dose is missed for more than 6 hours.
■ If vomiting occurs after taking the medicine, you can’t take it up, and the next time you take the medicine, you should follow the original interval.

[Adverse reaction of Retevmo (selpercatinib)]
The most common adverse reactions include: increased liver enzyme level; High blood sugar; Leukopenia; Decreased albumin in blood; Hypocalcemia; Dry mouth; Diarrhea; Elevated creatinine; Alkaline phosphatase increased; Hypertension; Weakness; Edema; Thrombocytopenia; Elevated cholesterol; Rash; Hyponatremia and constipation.

[Retevmo (selpercatinib) is used in special people]
■ Pregnancy: Animal experiments show that this drug may have potential fetal death and malformation.
■ Breastfeeding: Because breast-fed children may have serious adverse reactions, it is recommended that women do not breast-feed during the treatment period of taking this medicine and within one week after stopping taking it.
■ This medicine may affect the fertility of men and women.