IWILFIN(eflornithine，依氟鸟氨酸)

[IWILFIN indications]

IWILFIN is an ornithine decarboxylase inhibitor, which is suitable for reducing the recurrence risk of adults and children with high-risk neuroblastoma (HRNB). These patients have at least partially responded to previous multi-drug and multi-mode therapies (including anti-GD2 immunotherapy).

[dosage and administration of IWILFIN]

Before starting using IWILFIN, baseline audiogram, whole blood cell count and liver function test were performed.

The recommended dose of iwilfin is based on body surface area (see Table 1).

Table 1: Recommended Dosage
IWILFIN(eflornithine) _ Hong Kong Jimin Pharmaceutical
Iwilfin is taken orally twice a day, regardless of whether it is taken with food or not, until the disease progresses, unacceptable toxicity or up to two years.

Iwilfin tablets can be swallowed whole, chewed or crushed and mixed with soft food or liquid.

[IWILFIN contraindications]

None.

[IWILFIN warnings and precautions]

Bone marrow suppression: blood cell count was monitored before and during IWILFIN treatment. According to the severity, suspend, reduce the dose or stop the drug permanently.

Hearing loss: hearing was monitored before and during IWILFIN treatment. According to the severity, suspend, reduce the dose or stop the drug permanently.

Embryo-fetal toxicity: can cause fetal injury. Advise the potential risks of female reproductive potential to the fetus and use effective contraceptive measures.

Hepatotoxicity: liver function tests were monitored before and during IWILFIN treatment. According to the severity, suspend, reduce the dose or stop the drug permanently.

[IWILFIN is used in special people]

Breastfeeding: It is not recommended to breastfeed.

[Adverse reaction of IWILFIN]

The most common adverse reactions (incidence ≥5%) are hearing loss, otitis media, fever, pneumonia and diarrhea.

The most common grade 3 or 4 laboratory abnormalities (incidence ≥2%) are elevation of ALT, elevation of AST, decrease of neutrophil count and decrease of hemoglobin.