诺瓦得士(Tamoxifen他莫昔芬片Nolvadex)

【Function and Indications】
Nolvadex (Tamoxifen) is a non-steroidal anti-estrogen drug. It inhibits the proliferation of breast cancer cells by preventing the effect of estrogen. It is suitable for the treatment of advanced breast cancer and ovarian cancer.

【Model and Specification】
20mg/30 tablets

【Usage and Dosage】
Oral: 10-20mg each time, twice a day, can be used continuously. Or follow the doctor’s advice!

【Clinical Research】
Tamoxifen is a non-steroidal anti-estrogen drug. Its structure is similar to estrogen, and there are two isomers, Z type and E type. The two have different physical and chemical properties and physiological activities. The E type has weak estrogen activity, while the Z type has anti-estrogen effect. If there are estrogen receptors (ER) in breast cancer cells, estrogen enters the tumor cells and binds to them, promoting the synthesis of DNA and m-RNA in tumor cells and stimulating tumor cell growth. The Z-isomer of tamoxifen enters the cell, competes with ER for binding, forms a receptor complex, blocks the effect of estrogen, and thus inhibits the proliferation of breast cancer cells.

[Precautions]
Those with abnormal liver function should use it with caution. If there is bone metastasis, blood calcium should be checked regularly in the early stage of treatment.

[Adverse reactions and contraindications]
1. Adverse reactions include nausea, vomiting, diarrhea, menstrual disorders, vaginal bleeding, facial flushing, hair loss, rash, headache, dizziness, weight gain, edema, bone pain, and pain at the tumor site. Long-term and large-scale use may cause visual impairment, and occasionally leukocytopenia and thrombocytopenia.
2. It has an impact on the fetus and is contraindicated for pregnant women.
3. It should be used with caution for those with abnormal blood counts and liver and kidney function.
4. Occasionally, there is perineal itching and increased leucorrhea.
5. Sometimes it can cause hypercalcemia, which occurs within 1 to 2 weeks.

[Contraindications]
It has an impact on the fetus and is contraindicated for pregnant and lactating women.

[Pregnant women use]
It has an impact on the fetus and is contraindicated for pregnant and lactating women.

[Children use]
It is not recommended for children.

[Drug interactions]
Estrogen can affect the therapeutic effect of this product; antacids, cimetidine, ranitidine, etc. change the pH value in the stomach, causing the casing of this product to decompose prematurely, which can irritate the stomach.

[Storage]
Store at room temperature away from light.

[Manufacturer]
AstraZeneca Pharmaceuticals.