凯德(CALSED)盐酸氨柔比星

【Function and Indications】
This is an injection for the treatment of small cell lung cancer launched in Japan in 2002.

【Model and Specification】
Powder injection, each containing 20mg (potency) or 50mg of this product.

【Usage and Dosage】
The recommended dose for adults is 45mg (potency)/m2 per day, once a day, intravenously administered for 3 consecutive days. 3 to 4 weeks is a course of treatment, and the drug is discontinued after a course of treatment. The dose can be appropriately reduced in the next course of treatment according to the patient’s condition.
When used, dissolve this product in 20ml of normal saline or 5% glucose injection.

【Clinical Research】
This is an injection for the treatment of small cell lung cancer launched in Japan in 2002. It is the world’s first fully synthetic drug. It targets the DNA helix of cancer cells and cuts off the combination of Topoisomerase2 protein, thereby preventing the growth and division of cancer cells. It is a global first. From the clinical results, its therapeutic effect on small cell lung cancer exceeds all known drugs. It is a special therapeutic drug. Due to patents, domestic drug supervision and management, this drug has not yet been launched in China. However, domestic professional clinicians are very familiar with this drug, and many clinicians recommend patients to use this drug, but they have no channels to purchase it. Moreover, domestic counterfeits are prevalent, and people often lament that they have spent a sky-high price to buy counterfeit drugs. Our company has very good cooperation channels with Japanese drug dealers and can solve your drug purchase needs.

[Precautions]
Use with caution in patients with symptoms of myeloid function suppression, liver dysfunction, renal dysfunction, infected people, elderly patients and chickenpox patients.
No studies on the safety of children’s use have been conducted, so children should carefully observe possible adverse reactions when using this product and use it with caution. In addition, for children and patients of childbearing age who must use the drug, the effect of this product on gonadal function should be considered.
This product has obvious adverse reactions to liver and kidney function, and patients with liver and kidney dysfunction should be closely monitored when using the drug.

[Adverse reactions and contraindications]
The main adverse reactions of this product include leukopenia (93.9%, 170 cases/181 cases), neutropenia (95.0%, 172 cases/181 cases), hemoglobin decrease (81.2%, 147 cases/181 cases), thrombocytopenia (47.0%, 85 cases/181 cases), nausea and vomiting (58.6%, 106 cases/181 cases), hair loss (70.4%, 126 cases/181 cases), ALT (GPT) increase (22.7%, 41 cases/181 cases), AST (GOT) increase (17.1%, 31 cases/181 cases) and fever (29.8%, 54 cases/181 cases).
Occasional serious adverse reactions include interstitial pneumonia (0.1% to 5%), hematemesis (0.1% to 5%), electrocardiogram abnormalities (more than 5%), (cases/181 cases), loss of appetite (65.7%, 119 arrhythmias (0.1% to 5%) and rash (0.1% to 5%).

[Manufacturer]
Developed by Sumitomo Pharmaceuticals, Japan