Adstiladrin(nadofaragene firadenovec-vncg)

[indications of adstiladrin (nadofaragene firedenovic)]
It can be used to treat adult patients with carcinoma in situ (CIS) and non-papillary tumors of high-risk non-muscle invasive bladder cancer (NMIBC) who are ineffective in BCG.

[contraindication of adstiladrin (nadofaragene firedenovic)]
Adstiladrin is prohibited in patients who are allergic to interferon α or any component of this product.

[Adstiladrin (Nadofaragene Firedenovic) Warning and Precautions]
1. Delayed cystectomy may lead to the development of metastatic bladder cancer, which may be fatal.
2. Risk of disseminated gonadal virus infection: People with low immune function or immunodeficiency may be at risk of disseminated infection of Adstiladrin due to low level of replication-competent adenovirus. Avoid exposing Adstiladrin to immunocompromised or immunodeficient individuals.
3. Adstiladrin was administered only by intravesical perfusion.
4.Adstiladrin cannot be used for intravenous injection, local use or oral administration.

[Adverse reaction of adstiladrin (nadofaragene firedenovic)]
The most common (> 10%) adverse reactions (including laboratory abnormalities (> 15%) include elevated blood sugar (38%), discharge from drip site (33%), elevated triglyceride (30%), fatigue (24%), bladder spasm (20%) and micturition (urgency) (19%).